4/17/2023 0 Comments Thalassemia minor supplements![]() ![]() ![]() Transfusion-dependent patients will develop iron overload and require chelation therapy to remove the excess iron. ![]() Beta thalassemia intermedia is less severe than beta thalassemia major and may require episodic blood transfusions. Affected children will require regular lifelong blood transfusions. Beta thalassemia major causes hemolytic anemia, poor growth, and skeletal abnormalities during infancy. Alpha thalassemia major with hemoglobin Bart's usually results in fatal hydrops fetalis. Alpha thalassemia intermedia, or hemoglobin H disease, causes hemolytic anemia. Silent carriers of alpha thalassemia and persons with alpha or beta thalassemia trait are asymptomatic and require no treatment. Imbalances of globin chains cause hemolysis and impair erythropoiesis. Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of beta globin chains. The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains.
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